Menopause is the permanent cessation of menstruation at the end of the reproductive life due to loss of ovarian follicular activity. The prevalence of hypertension in women increases after menopause, suggesting that an absence of female gonadal steroids may represent a major risk factor for postmenopausal hypertension. Menopause is the phase from where bone mineralization becomes critics because of various physiological and hormonal changes. Estrogen deficiency and age related processes alter the rate of calcium turnover in bone that the ageing women face. Both systolic and diastolic blood pressure is significantly higher and serum calcium level is significantly lower among post menopausal women as compared with reproductive aged women. The objective of the study was to assess the blood pressure and serum calcium level changes in healthy postmenopausal women in order to compare this parameter with healthy reproductive aged women. This comparative study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from July 2018 to June 2019. Two hundred healthy women (100 female were postmenopausal as study group and 100 female were reproductive aged women as control group) aged between 25 to 65 years were enrolled in this study. Blood pressure was measured by indirect auscultatory method with an aneroid sphygmomanometer and serum calcium level of the individual was measured by enzymatic colorimetric method with o-cresoftaline-complexon. Data were expressed as mean±SD and statistical significance of difference among the group was calculated by unpaired students' 't' test. The mean value ±SD of blood pressure was higher and serum calcium level was lower in postmenopausal group in comparison to the reproductive women group. This study concludes, blood pressure increases and serum calcium level decreases in postmenopausal women.