An Acridine-Based Fluorescent Sensor for Monitoring ClO- in Water Samples and Zebrafish

Su Chan Lee; Soyoung Park; Haeri So; Gyudong Lee; Ki-Tae Kim; Cheal Kim

doi:10.3390/s20174764

An Acridine-Based Fluorescent Sensor for Monitoring ClO^- in Water Samples and Zebrafish

Sensors (Basel). 2020 Aug 23;20(17):4764. doi: 10.3390/s20174764.

Authors

Su Chan Lee¹, Soyoung Park¹, Haeri So¹, Gyudong Lee², Ki-Tae Kim², Cheal Kim¹

Affiliations

¹ Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul 136-741, Korea.
² Department of Environmental Engineering, Seoul National University of Science and Technology, Seoul 136-741, Korea.

Abstract

A novel acridine-based fluorescent chemosensor, BK ((E)-2-((acridine-9-ylimino)methyl)-N-benzhydrylhydrazine-1-carbothioamide), for monitoring ClO^- was prepared. The sensor BK was synthesized by introducing a new synthetic route of making aldehyde group using formic hydrazide. Probe BK displayed notable fluorescence quenching in the presence of ClO^- and showed a great selectivity over other guest analytes. The detection limit was calculated to be 7.65 μM. Additionally, BK was satisfactorily applied for sensing ClO^- in water samples and zebrafish.

Keywords: acridine; fluorescent chemosensor; hypochlorite; theoretical calculations; zebrafish.

Publication types

Letter

MeSH terms

Acridines / chemistry*
Animals
Fluorescent Dyes / chemistry*
Hypochlorous Acid / analysis*
Water / analysis*
Zebrafish*

Substances

Acridines
Fluorescent Dyes
Water
Hypochlorous Acid