Doppler Activity and Ultrasonographic Detection of Intra-Abdominal Fistulas Are Predictors of Surgery in Crohn's Disease

Dig Dis. 2021;39(3):204-210. doi: 10.1159/000511075. Epub 2020 Aug 24.

Abstract

Bakground and Aim: Predictors of the need for surgery in sticturing Crohn's disease (SCD) are lacking. Bowel ultrasound (US) is a harmless, noninvasive, and inexpensive diagnostic procedure that has proven to be a valuable tool in the management of Crohn's disease (CD). Our aim was to identify ultrasonographic findings in SCD that may associate with a higher risk of surgery, allowing us to make early choices regarding treatment election in this specific group of patients.

Materials and methods: This was a retrospective, case-control study. Twenty-four patients diagnosed with SCD between 2013 and 2017 with a past history of stricture-related surgery were included and then matched with 46 non-operated controls. Prior US from patients in both groups were analyzed. US features considered for analysis were as follows: bowel wall thickness, degree of parietal vascularization (measured by Doppler activity), prestenotic dilation, involvement of mesenteric fat, and newly detected concomitant fistulas or abscess.

Results: Doppler activity (p < 0.001), enteroenteric fistulas (p = 0.04), enteromesenteric fistulas (p = 0.003), and associated abscess (p = 0.004) were significantly associated with the need for surgery in the short-term period. Multivariate analysis showed strong association of these features with the risk of surgery but failed to reach statistical significance.

Conclusion: US features may potentially be used as point-of-care tools to aid clinicians in the assessment of the surgical risk in patients with SCD.

Keywords: Crohn’s disease; Inflammatory bowel diseases; Surgery; Ultrasonography.

MeSH terms

  • Abdomen / surgery*
  • Adult
  • Case-Control Studies
  • Crohn Disease / diagnostic imaging*
  • Crohn Disease / surgery*
  • Female
  • Fistula / diagnostic imaging*
  • Fistula / surgery*
  • Humans
  • Male
  • Multivariate Analysis
  • Retrospective Studies
  • Risk Factors
  • Ultrasonography, Doppler*