Prospects of Rescuing Young Eggs for Oncofertility

Michael J Bertoldo; Johan Smitz; Lindsay E Wu; Hoi Chang Lee; Teresa K Woodruff; Robert B Gilchrist

doi:10.1016/j.tem.2020.07.004

Prospects of Rescuing Young Eggs for Oncofertility

Trends Endocrinol Metab. 2020 Oct;31(10):708-711. doi: 10.1016/j.tem.2020.07.004. Epub 2020 Aug 14.

Authors

Michael J Bertoldo¹, Johan Smitz², Lindsay E Wu³, Hoi Chang Lee⁴, Teresa K Woodruff⁴, Robert B Gilchrist⁵

Affiliations

¹ Fertility and Research Centre, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW 2052, Australia; School of Medical Sciences, University of New South Wales Sydney, Sydney, NSW 2052, Australia. Electronic address: michael.bertoldo@unsw.edu.au.
² Follicle Biology Laboratory, UZ Brussel, Vrije Universiteit Brussel, Brussels 1050, Belgium.
³ School of Medical Sciences, University of New South Wales Sydney, Sydney, NSW 2052, Australia.
⁴ Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
⁵ Fertility and Research Centre, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW 2052, Australia.

PMID: 32807599
DOI: 10.1016/j.tem.2020.07.004

Abstract

Childhood cancer patients undergoing cancer therapy can be rendered infertile during adulthood. With more girls surviving cancer, fertility preservation in young cancer patients is a major clinical challenge. Advances in egg culture may offer benefits for the fertility of these patients in the future.

Keywords: cancer survival; fertility preservation; infertility; oocyte in vitro maturation; oocyte quality.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cancer Survivors*
Child
Cryopreservation*
Female
Fertility Preservation*
Humans
Oocytes*