Abstract
DSPG had a definite but relatively feeble immunosuppressive effect in rats undergoing heterotopic heart transplantation and in dogs after renal transplantation. The drug was toxic in both species, although less so in rats. In dogs, synergistic interactions with cyclosporine and steroids were not evident.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cyclosporins / administration & dosage
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Dogs
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Drug Therapy, Combination
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Graft Rejection / drug effects
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Guanidines / administration & dosage
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Guanidines / therapeutic use
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Guanidines / toxicity
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Heart Transplantation*
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Immunosuppressive Agents / therapeutic use*
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Immunosuppressive Agents / toxicity
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Kidney Transplantation*
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Prednisone / administration & dosage
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Rats
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Rats, Inbred ACI / immunology
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Rats, Inbred Lew / immunology
Substances
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Cyclosporins
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Guanidines
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Immunosuppressive Agents
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gusperimus
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Prednisone