Polyreactive Antibodies Bridge Immunity Particles to Pathogen

Henrique Machado; Luisa M Figueiredo

doi:10.1016/j.pt.2020.07.012

Polyreactive Antibodies Bridge Immunity Particles to Pathogen

Trends Parasitol. 2020 Oct;36(10):804-806. doi: 10.1016/j.pt.2020.07.012. Epub 2020 Aug 10.

Authors

Henrique Machado¹, Luisa M Figueiredo²

Affiliations

¹ Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-048 Lisboa, Portugal.
² Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-048 Lisboa, Portugal. Electronic address: lmf@medicina.ulisboa.ptlmf@medicina.ulisboa.pt.

PMID: 32792213
DOI: 10.1016/j.pt.2020.07.012

Abstract

Humans are protected from most African trypanosomes via high-density lipoproteins, known as trypanosome lytic factor (TLF). In humans, IgM antibodies are found associated with TLF. The recent work by Verdi et al. studied the origin of these antibodies and their binding partners, suggesting a new model for TLF uptake.

Keywords: IgM; antibodies; innate immunity; trypanosome lytic factor; trypanosomes; trypanosomiasis.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Germ Cells
Humans
Lipoproteins, HDL
Parasites*
Trypanosoma brucei brucei*
Trypanosoma*

Substances

Lipoproteins, HDL