Photocatalytic Hydroacylation of Alkenes by Directly Using Acyl Oximes

J Org Chem. 2020 Sep 18;85(18):11989-11996. doi: 10.1021/acs.joc.0c01818. Epub 2020 Sep 1.

Abstract

Acyl oximes are directly used as the acyl radical precursors in the hydroacylation reactions for the first time. In this work, acyl radicals can be effectively generated via β-scission of a phosphoranyl radical under photocatalytic conditions. As a result, the hydroacylation of alkenes triggered by the resulting acyl radicals leads to facile syntheses of a range of valuable ketones.