Rtpca: an R package for differential thermal proximity coaggregation analysis

Nils Kurzawa; André Mateus; Mikhail M Savitski

doi:10.1093/bioinformatics/btaa682

Rtpca: an R package for differential thermal proximity coaggregation analysis

Bioinformatics. 2021 Apr 20;37(3):431-433. doi: 10.1093/bioinformatics/btaa682.

Authors

Nils Kurzawa^{1

2}, André Mateus¹, Mikhail M Savitski¹

Affiliations

¹ European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany.
² Candidate for Joint PhD Between EMBL and Heidelberg University, Faculty of Biosciences, 69120 Heidelberg, Germany.

Abstract

Summary: Rtpca is an R package implementing methods for inferring protein-protein interactions (PPIs) based on thermal proteome profiling experiments of a single condition or in a differential setting via an approach called thermal proximity coaggregation. It offers user-friendly tools to explore datasets for their PPI predictive performance and easily integrates with available R packages.

Availability and implementation: Rtpca is available from Bioconductor (https://bioconductor.org/packages/Rtpca).

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Expression Profiling*
Software*