Peroxisomal Membrane Contact Sites in Mammalian Cells

Chao Chen; Jing Li; Xuhui Qin; Wei Wang

doi:10.3389/fcell.2020.00512

Peroxisomal Membrane Contact Sites in Mammalian Cells

Front Cell Dev Biol. 2020 Jun 23:8:512. doi: 10.3389/fcell.2020.00512. eCollection 2020.

Authors

Chao Chen¹, Jing Li², Xuhui Qin³, Wei Wang³

Affiliations

¹ Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Department of Human Anatomy, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

Peroxisomes participate in essential cellular metabolic processes, such as oxidation of fatty acids (FAs) and maintenance of reactive oxygen species (ROS) homeostasis. Peroxisomes must communicate with surrounding organelles to exchange information and metabolites. The formation of membrane contact sites (MCSs), where protein-protein or protein-lipid complexes tether the opposing membranes of two organelles, represents an essential means of organelle crosstalk. Peroxisomal MCS (PO-MCS) studies are emerging but are still in the early stages. In this review, we summarize the identified PO-MCSs with the ER, mitochondria, lipid droplets, and lysosomes in mammalian cells and discuss their tethering mechanisms and physiological roles. We also highlight several features of PO-MCSs that may help future studies.

Keywords: membrane contact sites; metabolism; organelle crosstalk; peroxisomes; tethering complexes.

Publication types

Review