Abstract
Since the end of 2019, a new type of coronavirus pneumonia (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout the world. Previously, there were two outbreaks of severe coronavirus caused by different coronaviruses worldwide, namely Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). This article introduced the origin, virological characteristics and epidemiological overview of SARS-CoV-2, reviewed the currently known drugs that may prevent and treat coronavirus, explained the characteristics of the new coronavirus and provided novel information for the prevention and treatment of COVID-19.
Keywords:
COVID-19; SARS-CoV-2; clinical treatment; drugs.; virological characteristics.
© The author(s).
MeSH terms
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Amides / pharmacology
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Amides / therapeutic use
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Antibodies, Monoclonal / therapeutic use
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Antiviral Agents / pharmacology
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Antiviral Agents / therapeutic use
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Betacoronavirus* / isolation & purification
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Betacoronavirus* / physiology
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COVID-19
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COVID-19 Drug Treatment
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Chloroquine / analogs & derivatives
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Chloroquine / therapeutic use
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Chlorpromazine / therapeutic use
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Coronavirus / genetics
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Coronavirus Infections / drug therapy*
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Coronavirus Infections / genetics
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Coronavirus Infections / prevention & control*
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Cyclophilins / antagonists & inhibitors
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Drug Development
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Drug Repositioning
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Drugs, Chinese Herbal / therapeutic use
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Endocytosis / drug effects
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Humans
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Immune Sera
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Interferon Inducers / therapeutic use
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Nucleic Acid Synthesis Inhibitors / pharmacology
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Nucleic Acid Synthesis Inhibitors / therapeutic use
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Pandemics / prevention & control*
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Pneumonia, Viral / drug therapy*
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Pneumonia, Viral / genetics
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Pneumonia, Viral / prevention & control*
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Pyrazines / pharmacology
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Pyrazines / therapeutic use
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Resveratrol / pharmacology
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Resveratrol / therapeutic use
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SARS-CoV-2
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Viral Vaccines / therapeutic use
Substances
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Amides
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Antibodies, Monoclonal
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Antiviral Agents
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Drugs, Chinese Herbal
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Immune Sera
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Interferon Inducers
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Nucleic Acid Synthesis Inhibitors
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Pyrazines
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Viral Vaccines
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chloroquine diphosphate
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Chloroquine
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Cyclophilins
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favipiravir
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Resveratrol
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Chlorpromazine