Getting intimate: Lysosomes and ER rendezvous to control autophagy

Philippe Pihán; Claudio Hetz

doi:10.1016/j.ceca.2020.102249

Getting intimate: Lysosomes and ER rendezvous to control autophagy

Cell Calcium. 2020 Nov:91:102249. doi: 10.1016/j.ceca.2020.102249. Epub 2020 Jul 17.

Authors

Philippe Pihán¹, Claudio Hetz²

Affiliations

¹ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
² Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA, 94945, USA. Electronic address: chetz@med.uchile.cl.

PMID: 32711245
DOI: 10.1016/j.ceca.2020.102249

Abstract

The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 -a putative ER calcium channel and cell death regulator -promotes calcium transfer from the ER to lysosomes to induce autophagy uncovers a missing piece in the puzzle of inter-organelle communication.

Keywords: Autophagy; Calcium; ER stress; Lysosome; Protein misfolding; UPR.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autophagy*
Calcium / metabolism
Endoplasmic Reticulum / metabolism*
Humans
Hydrogen-Ion Concentration
Lysosomes / metabolism*
Models, Biological

Substances

Calcium