The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression

Yang Liu; Xinjie Yu; Jianxin Zhao; Hao Zhang; Qixiao Zhai; Wei Chen

doi:10.1016/j.ijbiomac.2020.07.191

The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression

Int J Biol Macromol. 2020 Dec 1:164:884-891. doi: 10.1016/j.ijbiomac.2020.07.191. Epub 2020 Jul 22.

Authors

Yang Liu¹, Xinjie Yu², Jianxin Zhao¹, Hao Zhang³, Qixiao Zhai⁴, Wei Chen⁵

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
² Hwa Chong Institution (College), 661 Bukit Timah Road, Singapore 269734, Singapore.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China.
⁴ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: zhaiqixiao@sina.com.
⁵ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.

PMID: 32707285
DOI: 10.1016/j.ijbiomac.2020.07.191

Abstract

MUC2 mucin is an important secretory protein found in the human gut. Recent studies indicated that MUC2 mucin plays a role in the protection of gut barrier, the regulation of microbiome homeostasis and the prevention of diseases. In this review, the physiological properties of MUC2 mucin and its interactions with the intestinal microbiome are firstly discussed. Its roles in intestinal diseases including inflammatory bowel disease, colorectal cancer and parasitic infections are concluded. We also reviewed dietary components known to have modulative effects on MUC2 mucin expression, such as polysaccharides, amino acids and polyphenols.

Keywords: Intestinal diseases; Intestinal microbiota; MUC2 mucin.

Publication types

Review

MeSH terms

Amino Acids / metabolism
Animals
Colitis / metabolism
Colorectal Neoplasms / metabolism
Colorectal Neoplasms / microbiology
Diet*
Gastrointestinal Microbiome*
Goblet Cells / metabolism
HT29 Cells
Homeostasis*
Humans
Inflammatory Bowel Diseases / metabolism
Inflammatory Bowel Diseases / microbiology
Intestinal Mucosa / metabolism
Intestines / microbiology*
Mice
Mucin-2 / metabolism*
Mucins / metabolism
Parasitic Diseases / metabolism
Parasitic Diseases / microbiology
Polyphenols / metabolism
Polysaccharides / metabolism
Trace Elements

Substances

Amino Acids
MUC2 protein, human
Muc2 protein, mouse
Mucin-2
Mucins
Polyphenols
Polysaccharides
Trace Elements