The structure of (1,2-benzisoxazol-3-yl)methanesulfonamide: a novel antiepileptic drug

Acta Crystallogr C. 1988 Nov 15:44 ( Pt 11):2013-6. doi: 10.1107/s0108270188008704.

Abstract

C8H8N2O3S, Mr = 212.54, monoclinic, P2(1)/a, a = 7.347 (9), b = 13.237 (4), c = 10.128 (8) A, beta = 108.916 (6) degree, V = 931.9 (1) A3, Z = 4, Dm = 1.52 (4), Dx = 1.514 g cm-3, lambda (Cu K alpha) = 1.54184 A, mu = 28.35 cm-1, F(000) = 440, room temperature, R = 0.040 for 1864 observed reflections. The sulfonamide N forms intermolecular hydrogen bonds with the benzisoxazole ring N and also with the O on the sulfonamide group. Centrosymmetrically related benzisoxazole ring pairs are pi bonded with a high degree of overlap.

MeSH terms

  • Anticonvulsants*
  • Hydrogen Bonding
  • Isoxazoles*
  • Models, Molecular
  • Molecular Conformation
  • Oxazoles*
  • X-Ray Diffraction
  • Zonisamide

Substances

  • Anticonvulsants
  • Isoxazoles
  • Oxazoles
  • Zonisamide