Influence of immunosuppression on seroconversion against SARS-CoV-2 in two kidney transplant recipients

Transpl Infect Dis. 2021 Feb;23(1):e13423. doi: 10.1111/tid.13423. Epub 2020 Aug 8.

Abstract

Solid organ transplant recipients are at risk for infectious complications due to chronic immunosuppression. The outbreak of coronavirus disease 2019 (COVID-19) in the United States has raised growing concerns for the transplant patient population. We seek to add to the current limited literature on COVID-19 in transplant recipients by describing the clinical course of two kidney transplant recipients with SARS-CoV-2 infection monitored by both RT-PCR and serology. Through careful adjustment of their immunosuppression regimen, both patients had excellent recovery with intact graft function and development of anti-SARS-CoV-2 antibodies.

Keywords: COVID-19; RT-PCR; SARS-CoV-2; antibodies; immunosuppression; seroconversion.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / administration & dosage*
  • Immunosuppressive Agents / therapeutic use*
  • Kidney Transplantation*
  • Middle Aged
  • SARS-CoV-2*
  • Seroconversion
  • Transplant Recipients*

Substances

  • Immunosuppressive Agents