Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson's disease carrying variants in PRKN and HTRA2

Yubo Yan; Suihan Wu; Lixiang Jiang; Bo Yang; Xuhui Chen; Yuqing Liu; Baorong Yu; Jian Fu; Jin Yu; Hui Ning; Meng Chu; Jiayin Yang

doi:10.1016/j.scr.2020.101905

Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson's disease carrying variants in PRKN and HTRA2

Stem Cell Res. 2020 Jul 3:47:101905. doi: 10.1016/j.scr.2020.101905. Online ahead of print.

Authors

Yubo Yan¹, Suihan Wu², Lixiang Jiang¹, Bo Yang¹, Xuhui Chen³, Yuqing Liu¹, Baorong Yu¹, Jian Fu¹, Jin Yu², Hui Ning², Meng Chu⁴, Jiayin Yang⁵

Affiliations

¹ Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China.
² Department of Obstetrics, Qingdao Municipal Hospital, Qingdao 266000, China.
³ Department of Neurology, Peking University Shenzhen Hospital, Shenzhen 518000, China.
⁴ Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China. Electronic address: chumeng89@126.com.
⁵ Laboratory of iPSC and Disease Models, Cell Inspire Biotechnology Co., Ltd., Shenzhen 518101, China; Cell Inspire Therapeutics Co., Ltd., Shenzhen 518101, China. Electronic address: jyyang@cib.cc.

PMID: 32688332
DOI: 10.1016/j.scr.2020.101905

Abstract

Variations in PRKN or HTRA2 are associated with Parkinson's disease. We generated a human induced pluripotent stem cell (iPSC) line CIBi007-A from a patient with young-onset Parkinson's disease (YOPD) who carried variants in PRKN and HTRA2. The generated iPSCs resembled human embryonic stem cells, expressed pluripotency markers, exhibited a normal karyotype, and could be differentiated into three germ layers in vitro. This line will be valuable for investigating disease mechanisms of YOPD and screening candidate drugs.