Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients

Jiangping He; Shuijiang Cai; Huijian Feng; Baomei Cai; Lihui Lin; Yuanbang Mai; Yinqiang Fan; Airu Zhu; Huang Huang; Junjie Shi; Dingxin Li; Yuanjie Wei; Yueping Li; Yingying Zhao; Yuejun Pan; He Liu; Xiaoneng Mo; Xi He; Shangtao Cao; FengYu Hu; Jincun Zhao; Jie Wang; Nanshan Zhong; Xinwen Chen; Xilong Deng; Jiekai Chen

doi:10.1007/s13238-020-00752-4

Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients

Protein Cell. 2020 Sep;11(9):680-687. doi: 10.1007/s13238-020-00752-4.

Authors

Jiangping He^{1

2

3}, Shuijiang Cai⁴, Huijian Feng^{1

2

3

5}, Baomei Cai^{1

2

3}, Lihui Lin^{1

2

3

5}, Yuanbang Mai^{1

2

3}, Yinqiang Fan⁴, Airu Zhu⁶, Huang Huang⁴, Junjie Shi^{1

2

3}, Dingxin Li^{1

2

3}, Yuanjie Wei^{1

2

3}, Yueping Li⁴, Yingying Zhao^{1

2

3}, Yuejun Pan⁴, He Liu^{1

2

3}, Xiaoneng Mo⁴, Xi He⁴, Shangtao Cao^{1

2

3}, FengYu Hu⁴, Jincun Zhao⁶, Jie Wang^{1

2

3}, Nanshan Zhong⁶, Xinwen Chen^{7

8}, Xilong Deng⁹, Jiekai Chen^{10

11

12}

Affiliations

¹ Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
² The Centre of Cell Lineage and Atlas (CCLA), Guangzhou Regenerative Medicine and Health-Guangdong Laboratory, Guangzhou, 510530, China.
³ Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
⁴ Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
⁵ University of the Chinese Academy of Sciences, Beijing, 100049, China.
⁶ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
⁷ Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_xinwen@gibh.ac.cn.
⁸ Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_xinwen@gibh.ac.cn.
⁹ Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China. gz8hdxl@126.com.
¹⁰ Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_jiekai@gibh.ac.cn.
¹¹ The Centre of Cell Lineage and Atlas (CCLA), Guangzhou Regenerative Medicine and Health-Guangdong Laboratory, Guangzhou, 510530, China. chen_jiekai@gibh.ac.cn.
¹² Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_jiekai@gibh.ac.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Betacoronavirus*
COVID-19
Coronavirus Infections*
Humans
Pandemics*
Pneumonia, Viral*
SARS-CoV-2
Single-Cell Analysis