The First Case of Concomitant Mycobacterium Genavense Lymphadenitis and EBV-Positive Lymphoproliferative Disorder

Yusuke Ito; Kensuke Takaoka; Kazuhiro Toyama; Kazuki Taoka; Yoshitaka Wakabayashi; Aya Shinozaki-Ushiku; Aiko Okazaki; Kinuyo Chikamatsu; Satoshi Mitarai; Tetsuo Ushiku; Mineo Kurokawa

doi:10.4084/MJHID.2020.035

The First Case of Concomitant Mycobacterium Genavense Lymphadenitis and EBV-Positive Lymphoproliferative Disorder

Mediterr J Hematol Infect Dis. 2020 Jul 1;12(1):e2020035. doi: 10.4084/MJHID.2020.035. eCollection 2020.

Authors

Affiliations

¹ Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo.
² Department of Infectious Diseases, The University of Tokyo Hospital.
³ Department of Pathology, Graduate School of Medicine, The University of Tokyo.
⁴ Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association.
⁵ Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital.

Abstract

This is the first case of concurrent Mycobacterium genavense lymphadenitis and Epstein-Barr virus (EBV)-positive lymphoproliferative disorder (LPD) in the same lymph node with no immunocompromised history. M. genavense infection is a rare opportunistic infection mainly for human immunodeficiency virus (HIV)-infected patients. Although no immunodeficiency was detected in our patient, our case indicates that the immunodeficiency in the background of EBV latency type III and the immunosuppression by malignant lymphoma itself might induce the M. genavense lymphadenitis. This case highly alerts clinicians to the immunosuppressive state of EBV-positive LPD with latency type III even if any immunodeficient serological factors are not detected.

Keywords: Epstein-Barr virus-positive lymphoproliferative disorder (EBV-LPD); Mycobacterium genavense; Programmed cell death 1 ligand 1 (PD-L1).

Publication types

Case Reports