Performance of the Xpert MTB/RIF Ultra Assay for Determining Cause of Death by TB in Tissue Samples Obtained by Minimally Invasive Autopsies

Alberto L Garcia-Basteiro; Juan Carlos Hurtado; Paola Castillo; Fabiola Fernandes; Mireia Navarro; Lucilia Lovane; Isaac Casas; Llorenç Quintó; Dercio Jordao; Mamudo R Ismail; Cesaltina Lorenzoni; Carla Carrilho; Ariadna Sanz; Natalia Rakislova; Aurea Mira; Miriam J Alvarez-Martínez; Anélsio Cossa; Frank Cobelens; Inácio Mandomando; Jordi Vila; Quique Bassat; Clara Menendez; Jaume Ordi; Miguel J Martínez

doi:10.1016/j.chest.2020.06.071

Performance of the Xpert MTB/RIF Ultra Assay for Determining Cause of Death by TB in Tissue Samples Obtained by Minimally Invasive Autopsies

Chest. 2021 Jan;159(1):103-107. doi: 10.1016/j.chest.2020.06.071. Epub 2020 Jul 12.

Authors

Alberto L Garcia-Basteiro¹, Juan Carlos Hurtado², Paola Castillo³, Fabiola Fernandes⁴, Mireia Navarro⁵, Lucilia Lovane⁵, Isaac Casas⁵, Llorenç Quintó⁶, Dercio Jordao⁴, Mamudo R Ismail⁴, Cesaltina Lorenzoni⁴, Carla Carrilho⁴, Ariadna Sanz⁷, Natalia Rakislova⁸, Aurea Mira⁹, Miriam J Alvarez-Martínez², Anélsio Cossa⁶, Frank Cobelens¹⁰, Inácio Mandomando¹¹, Jordi Vila², Quique Bassat¹², Clara Menendez¹³, Jaume Ordi³, Miguel J Martínez¹⁴

Affiliations

¹ Centro de Investigaçãoem Saúde de Manhiça (CISM), Maputo, Mozambique; ISGlobal, Hospital Clínic, Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
² ISGlobal, Hospital Clínic, Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Department of Microbiology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
³ ISGlobal, Hospital Clínic, Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Department of Pathology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
⁴ Department of Pathology, Faculty of Medicine/Eduardo Mondlane University and Maputo Central Hospital, Maputo, Mozambique.
⁵ Department of Microbiology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
⁶ Centro de Investigaçãoem Saúde de Manhiça (CISM), Maputo, Mozambique.
⁷ ISGlobal, Hospital Clínic, Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain.
⁸ Department of Pathology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain.
⁹ Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain, Instituto Nacional de Saúde (INS), Ministério da Saúde, Maputo, Moçambique.
¹⁰ Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
¹¹ Centro de Investigaçãoem Saúde de Manhiça (CISM), Maputo, Mozambique; Biomedical Diagnostic Centre (CDB), Hospital Clínic, University of Barcelona, Barcelona, Spain, Instituto Nacional de Saúde (INS), Ministério da Saúde, Maputo, Moçambique.
¹² Centro de Investigaçãoem Saúde de Manhiça (CISM), Maputo, Mozambique; ISGlobal, Hospital Clínic, Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; ICREA, Catalan Institution for Research and Advanced Studies, Pg. Lluís Companys 23, Barcelona, Spain; Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu,University of Barcelona, Barcelona, Spain.
¹³ Centro de Investigaçãoem Saúde de Manhiça (CISM), Maputo, Mozambique; ISGlobal, Hospital Clínic, Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
¹⁴ ISGlobal, Hospital Clínic, Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain; Department of Microbiology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. Electronic address: myoldi@clinic.cat.

No abstract available

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Autopsy*
Cause of Death*
Child
Female
Humans
Male
Sensitivity and Specificity
Tuberculosis, Pulmonary / diagnosis*
Young Adult