CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

CG14906 (mettl4) mediates m⁶A methylation of U2 snRNA in Drosophila

Cell Discov. 2020 Jun 30:6:44. doi: 10.1038/s41421-020-0178-7. eCollection 2020.

Lei Gu^#^{1

2}, Longfei Wang^#^{3

4}, Hao Chen^#^{1

2}, Jiaxu Hong^#^{5

6}, Zhangfei Shen^{1

2}, Abhinav Dhall^{1

2}, Taotao Lao⁷, Chaozhong Liu^{1

2}, Zheng Wang^{1

2}, Yifan Xu^{1

2}, Hong-Wen Tang⁸, Damayanti Chakraborty^{1

2}, Jiekai Chen⁹, Zhihua Liu¹⁰, Dragana Rogulja¹⁰, Norbert Perrimon^{8

11}, Hao Wu^{3

4}, Yang Shi^{1

2}

¹ Department of Medicine, Division of Newborn Medicine and Epigenetics Programe, Boston Children's Hospital, Boston, MA 02115 USA.
² Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA.
³ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115 USA.
⁴ Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115 USA.
⁵ Department of Ophthalmology and Vision Science, Shanghai Eye, Ear, Nose and Throat Hospital, Fudan University, 200031 Shanghai, China.
⁶ Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004 China.
⁷ Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129 USA.
⁸ Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115 USA.
⁹ CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, Guangdong 510530 China.
¹⁰ Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA.
¹¹ Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115 USA.

^# Contributed equally.

No abstract available

Keywords: DNA methylation; Transcriptional regulatory elements.