Macromolecular crystallography beamlines at the Canadian Light Source: building on success

Acta Crystallogr D Struct Biol. 2020 Jul 1;76(Pt 7):630-635. doi: 10.1107/S2059798320007603. Epub 2020 Jun 19.

Abstract

The Canadian Macromolecular Crystallography Facility (CMCF) consists of two beamlines dedicated to macromolecular crystallography: CMCF-ID and CMCF-BM. After the first experiments were conducted in 2006, the facility has seen a sharp increase in usage and has produced a significant amount of data for the Canadian crystallographic community. Upgrades aimed at increasing throughput and flux to support the next generation of more demanding experiments are currently under way or have recently been completed. At CMCF-BM, this includes an enhanced monochromator, automounter software upgrades and a much faster detector. CMCF-ID will receive a major upgrade including a new undulator, a new monochromator and new optics to stably focus the beam onto a smaller sample size, as well as a brand-new detector.

Keywords: Canadian Light Source; beamline; double crystal/multi-layer monochromator; macromolecular crystallography.

MeSH terms

  • Canada
  • Crystallography, X-Ray / instrumentation*
  • Equipment Design*
  • Macromolecular Substances / chemistry*
  • Software*

Substances

  • Macromolecular Substances

Grants and funding

This work was funded by Canada Foundation for Innovation grant . Natural Sciences and Engineering Research Council of Canada grant . National Research Council Canada grant . Canadian Institutes of Health Research grant . Government of Saskatchewan grant . University of Saskatchewan grant .