Is Obesity a Disease of Stem Cells?

Arin K Oestreich; Kelsey H Collins; Natalia S Harasymowicz; Chia-Lung Wu; Farshid Guilak

doi:10.1016/j.stem.2020.04.019

Is Obesity a Disease of Stem Cells?

Cell Stem Cell. 2020 Jul 2;27(1):15-18. doi: 10.1016/j.stem.2020.04.019.

Authors

Arin K Oestreich¹, Kelsey H Collins¹, Natalia S Harasymowicz¹, Chia-Lung Wu¹, Farshid Guilak²

Affiliations

¹ Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA; Shriners Hospitals for Children, St. Louis, MO, USA; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO, USA.
² Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA; Shriners Hospitals for Children, St. Louis, MO, USA; Center of Regenerative Medicine, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: guilak@wustl.edu.

Abstract

Obesity disrupts physiological homeostasis and alters both systemic and local microenvironments that impact stem cell plasticity and impair regenerative capacity. We present growing evidence that reveals the bidirectionality of obesity-induced stem cell dysfunction and how the molecular changes in stem cells residing in obese environments may accelerate disease severity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Plasticity
Homeostasis
Humans
Obesity*
Stem Cells*

Abstract

Publication types

MeSH terms

Grants and funding