MGMT Promoter Methylation as a Target In Metastatic Colorectal Cancer: Rapid Turnover and Use of Folates Alter its Study-Response

Clin Cancer Res. 2020 Jul 1;26(13):3495. doi: 10.1158/1078-0432.CCR-20-0817.
No abstract available

Publication types

  • Letter
  • Comment

MeSH terms

  • Capecitabine
  • Colorectal Neoplasms* / drug therapy
  • Colorectal Neoplasms* / genetics
  • DNA Modification Methylases / genetics
  • DNA Modification Methylases / metabolism
  • DNA Repair Enzymes / genetics
  • DNA Repair Enzymes / metabolism
  • Humans
  • Methylation
  • Promoter Regions, Genetic
  • Temozolomide
  • Tumor Suppressor Proteins / genetics

Substances

  • Tumor Suppressor Proteins
  • Capecitabine
  • DNA Modification Methylases
  • MGMT protein, human
  • DNA Repair Enzymes
  • Temozolomide