Candida sepsis from local infection in a patient with a urostomy on SGLT2 inhibitor therapy

Int J Infect Dis. 2020 Sep:98:227-229. doi: 10.1016/j.ijid.2020.06.073. Epub 2020 Jun 24.

Abstract

Sodium-glucose co-transporter 2 (SGLT2) inhibitors exhibit impressive cardio-renal benefits in patients with a high cardiovascular risk. Genital yeast infections are important side effects of this class of drugs. We report a case of Candida glabrata sepsis secondary to a Candida infection of the urostomy of a patient on SGLT2 inhibitor therapy. In urostomy patients, one should critically evaluate the risk of mycotic infections against the cardiovascular and glycaemic benefits of SGLT2 inhibition. Urostomy patients without a high cardiovascular risk should not be treated with SGLT2 inhibitors.

Keywords: SGLT2 inhibitors; SGLT2i, Candida glabrata; Urostomy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Candida / drug effects
  • Candida / growth & development
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy
  • Humans
  • Hypoglycemic Agents / adverse effects*
  • Hypoglycemic Agents / therapeutic use
  • Male
  • Sepsis / etiology*
  • Sepsis / microbiology
  • Sodium-Glucose Transporter 2 Inhibitors / adverse effects*
  • Sodium-Glucose Transporter 2 Inhibitors / therapeutic use
  • Urine / microbiology

Substances

  • Hypoglycemic Agents
  • Sodium-Glucose Transporter 2 Inhibitors