Management of central nervous system relapse in a young patient affected by primary mediastinal large B-cell lymphoma: A case report

Miriam Marangon; Beatrice Casadei; Alessandro Broccoli; Lisa Argnani; Michele Cavo; Pier Luigi Zinzani

doi:10.1002/ccr3.2706

Management of central nervous system relapse in a young patient affected by primary mediastinal large B-cell lymphoma: A case report

Clin Case Rep. 2020 Apr 8;8(6):933-937. doi: 10.1002/ccr3.2706. eCollection 2020 Jun.

Authors

Miriam Marangon¹, Beatrice Casadei¹, Alessandro Broccoli¹, Lisa Argnani¹, Michele Cavo¹, Pier Luigi Zinzani¹

Affiliation

¹ Institute of Hematology "L. e A. Seràgnoli" University of Bologna Bologna Italy.

Abstract

In primary mediastinal large B-cell lymphoma, central nervous system (CNS) relapse is an uncommon event with a dismal prognosis. We report about the successful management of CNS relapse with chemoimmunotherapy according to MATRix (methotrexate, cytarabine, thiotepa, and rituximab) protocol followed by autologous stem cell transplant.

Keywords: MATRix regimen; autologous stem cell transplant; central nervous system involvement; primary mediastinal large B‐cell lymphoma.

Publication types

Case Reports