In Vitro Activities of Ravuconazole and Isavuconazole against Dematiaceous Fungi

Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00643-20. doi: 10.1128/AAC.00643-20. Print 2020 Aug 20.

Abstract

The in vitro activities of 11 antifungals against 84 dematiaceous fungi were tested. For most tested fungal species, the MIC values of ravuconazole and isavuconazole were lower than those obtained with itraconazole, voriconazole, and posaconazole. Ravuconazole and isavuconazole appear to be more efficient against most dematiaceous fungal infections than the other triazoles. However, some pigmented fungi, such as Bipolaris spicifera and Veronaea botryosa, remain more susceptible to other triazoles or to echinocandins.

Keywords: antifungal susceptibility; dematiaceous fungi; isavuconazole; ravuconazole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology
  • Ascomycota
  • Fungi*
  • Microbial Sensitivity Tests
  • Nitriles
  • Pyridines
  • Thiazoles
  • Triazoles* / pharmacology
  • Voriconazole

Substances

  • Antifungal Agents
  • Nitriles
  • Pyridines
  • Thiazoles
  • Triazoles
  • isavuconazole
  • ER 30346
  • Voriconazole

Supplementary concepts

  • Veronaea botryosa