Islet cell transplantation in children

Semin Pediatr Surg. 2020 Jun;29(3):150925. doi: 10.1016/j.sempedsurg.2020.150925. Epub 2020 May 23.

Abstract

This paper aims to provide an overview of islet cell transplantation in children, with specific attention to pediatric total pancreatectomy with islet autotransplantation (TPIAT). We will summarize the definition and causes of chronic pancreatitis in children, the TPIAT procedure and potential complications, the process of islet cell isolation and autotransplantation, and long-term results after TPIAT. Lastly, we will briefly discuss islet cell allotransplantation in the adult population and its potential role in treating children.

Keywords: Allotransplantation; Autotransplantation; Diabetes mellitus; Islet cell; Pancreatitis; Pediatrics.

Publication types

  • Review

MeSH terms

  • Adult
  • Child
  • Humans
  • Islets of Langerhans Transplantation / methods*
  • Pancreatectomy / methods*
  • Pancreatitis, Chronic / diagnosis
  • Pancreatitis, Chronic / etiology
  • Pancreatitis, Chronic / surgery*
  • Postoperative Complications / diagnosis
  • Postoperative Complications / therapy
  • Transplantation, Autologous / methods
  • Treatment Outcome