Classification of Histologic Images Using a Single Staining: Experiments with Deep Learning on Deconvolved Images

Stud Health Technol Inform. 2020 Jun 16:270:1223-1224. doi: 10.3233/SHTI200373.

Abstract

The automated analysis of digitized immunohistochemistry microscope slides is usually a challenging task, because markers should be analysed on the tumor area only. Tumor areas could be recognized on a different slide, stained with Haematoxylin-Eosin. The basic idea of the present poster is to evaluate how well deep learning methods perform on the single haematoxylin component of staining, with the prospective possibility of developing a classifier able to recognize tumor areas on IHC slides on their haematoxylin component only. In a preliminary experiment, single stain images obtained by H-E color deconvolution showed an accuracy of 0.808 and 0.812 for Hematoxilyn and Eosin components, respectively.

Keywords: Deep Learning; Digital slides; cancer.

MeSH terms

  • Deep Learning*
  • Humans
  • Image Interpretation, Computer-Assisted
  • Neoplasms
  • Prospective Studies
  • Staining and Labeling