Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19

Emmanuel Dudoignon; Nabila Moreno; Benjamin Deniau; Maxime Coutrot; Romain Longer; Quentin Amiot; Alexandre Mebazaa; Romain Pirracchio; François Depret; Matthieu Legrand

doi:10.1016/j.accpm.2020.06.006

Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19

Anaesth Crit Care Pain Med. 2020 Aug;39(4):453-455. doi: 10.1016/j.accpm.2020.06.006. Epub 2020 Jun 18.

Affiliations

¹ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris, Paris, France.
² Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Biochemistry, Paris, France.
³ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; Inserm UMR-S 942, Mascot, Lariboisière Hospital, Paris, France.
⁴ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France.
⁵ Department of Anesthesiology and Peri-operative Medicine and Critical Care Medicine, University of California, San Francisco, California.
⁶ Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France; University of Paris, Paris, France; Department of Anesthesiology and Peri-operative Medicine and Critical Care Medicine, University of California, San Francisco, California. Electronic address: matthieu.m.legrand@gmail.com.

Abstract

The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV-2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI.

Keywords: COVID-19; Renin-angiotensin-aldosterone system.

MeSH terms

Acute Kidney Injury / etiology
Acute Kidney Injury / metabolism*
Acute Kidney Injury / therapy
Aged
Aldosterone / blood
Betacoronavirus*
COVID-19
Coronavirus Infections / complications
Coronavirus Infections / metabolism*
Creatinine / blood
Critical Illness
Female
Humans
Intensive Care Units
Male
Middle Aged
Pandemics
Pneumonia, Viral / complications
Pneumonia, Viral / metabolism*
Renin-Angiotensin System / physiology*
SARS-CoV-2

Substances

Aldosterone
Creatinine