Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo

Cui Lv; Shoubing Chen; Fangxiao Hu; Dehao Huang; Tongjie Wang; Juan Du; Jinyong Wang; Hongling Wu

doi:10.1038/s41423-020-0429-4

Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo

Cell Mol Immunol. 2021 Mar;18(3):773-775. doi: 10.1038/s41423-020-0429-4. Epub 2020 Jun 15.

Authors

Cui Lv^#^{1

2

3}, Shoubing Chen^#^{1

2

3}, Fangxiao Hu^{1

2

3}, Dehao Huang^{2

3}, Tongjie Wang^{2

3}, Juan Du^{2

3

4

5}, Jinyong Wang^{6

7

8

9

10}, Hongling Wu^{11

12

13}

Affiliations

¹ School of Life Sciences, University of Science and Technology of China, Hefei, China.
² CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
³ Guangdong Provincial Key Laboratory of Stem cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
⁴ Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangdong, China.
⁵ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
⁶ School of Life Sciences, University of Science and Technology of China, Hefei, China. wang_jinyong@gibh.ac.cn.
⁷ CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. wang_jinyong@gibh.ac.cn.
⁸ Guangdong Provincial Key Laboratory of Stem cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. wang_jinyong@gibh.ac.cn.
⁹ Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangdong, China. wang_jinyong@gibh.ac.cn.
¹⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. wang_jinyong@gibh.ac.cn.
¹¹ CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. wu_hongling@gibh.ac.cn.
¹² Guangdong Provincial Key Laboratory of Stem cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. wu_hongling@gibh.ac.cn.
¹³ Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangdong, China. wu_hongling@gibh.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, CD19 / immunology*
Core Binding Factor Alpha 2 Subunit / metabolism
Hematopoietic Stem Cells / cytology
Hematopoietic Stem Cells / metabolism
Homeodomain Proteins / metabolism
Immunotherapy, Adoptive / methods*
Lymphoma, B-Cell / immunology
Lymphoma, B-Cell / metabolism
Lymphoma, B-Cell / therapy*
Mice
Mice, Inbred C57BL
Pluripotent Stem Cells / cytology*

Substances

Antigens, CD19
Core Binding Factor Alpha 2 Subunit
Homeodomain Proteins
Runx1 protein, mouse
homeobox protein HOXA9