Antimicrobial zinc toxicity in Mϕs: ZnT1 pays the toll

J Leukoc Biol. 2021 Feb;109(2):281-282. doi: 10.1002/JLB.4CE0520-256R. Epub 2020 Jun 12.

Abstract

Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB, Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contributes to zinc accumulation in Escherichia coli-containing phagosomes, resulting in increased bacterial clearance.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Anti-Infective Agents*
  • Cation Transport Proteins*
  • Zinc / metabolism

Substances

  • Anti-Infective Agents
  • Cation Transport Proteins
  • Zinc