Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

Chem Soc Rev. 2020 Jun 22;49(12):3863-3888. doi: 10.1039/c9cs00099b.

Abstract

This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, conformational, stability, reactivity and interaction features of fluorinated sugars are described, as well as their applications as probes and in chemical biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Carbohydrates / chemistry*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Glycosides / chemistry
  • Halogenation
  • Humans
  • Molecular Probes / chemistry*
  • Neoplasms / diagnostic imaging
  • Positron-Emission Tomography
  • Vaccines, Synthetic / chemistry
  • Vaccines, Synthetic / immunology

Substances

  • Carbohydrates
  • Enzyme Inhibitors
  • Glycosides
  • Molecular Probes
  • Vaccines, Synthetic