Pyroptosis Takes Aim at Neurodevelopment

Jaeda C Coutinho-Budd; Heather T Broihier

doi:10.1016/j.devcel.2020.05.013

Pyroptosis Takes Aim at Neurodevelopment

Dev Cell. 2020 Jun 8;53(5):498-499. doi: 10.1016/j.devcel.2020.05.013.

Authors

Jaeda C Coutinho-Budd¹, Heather T Broihier²

Affiliations

¹ Department of Biology, University of Vermont, Burlington, VT 05405, USA.
² Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44016, USA. Electronic address: heather.broihier@case.edu.

PMID: 32516594
DOI: 10.1016/j.devcel.2020.05.013

Abstract

In a recent issue of Nature, Lammert et al. demonstrate that DNA damage drives AIM2-mediated pyroptosis during normal brain development, preventing anxiety-like behaviors acquisition in adults and revealing an important role for non-apoptotic mechanisms of cell death during neurodevelopment.

Publication types

Comment

MeSH terms

Caspase 1 / genetics
DNA Damage
DNA-Binding Proteins / genetics
Inflammasomes*
Pyroptosis*

Substances

DNA-Binding Proteins
Inflammasomes
Caspase 1