Potential Roles of Total-Body PET/Computed Tomography in Pediatric Imaging

Lorenzo Nardo; Jeffrey P Schmall; Thomas J Werner; Marcio Malogolowkin; Ramsey D Badawi; Abass Alavi

doi:10.1016/j.cpet.2020.03.009

Potential Roles of Total-Body PET/Computed Tomography in Pediatric Imaging

PET Clin. 2020 Jul;15(3):271-279. doi: 10.1016/j.cpet.2020.03.009.

Authors

Lorenzo Nardo¹, Jeffrey P Schmall², Thomas J Werner³, Marcio Malogolowkin⁴, Ramsey D Badawi⁵, Abass Alavi⁶

Affiliations

¹ Department of Radiology, University of California, Davis, ACC building Suite 3100, Sacramento, California 95817, USA.
² Department of Radiology, University of California, Davis, ACC building Suite 3100, Sacramento, California 95817, USA; United Imaging Healthcare of America, Houston, TX, USA.
³ Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
⁴ Division of Pediatric Hematology-Oncology, UC Davis Children's Hospital UC Davis Comprehensive Cancer Center, University of California, Davis, Sacramento, California 95817, USA.
⁵ Department of Radiology, University of California, Davis, ACC building Suite 3100, Sacramento, California 95817, USA; Department Biomedical Engineering, University of California, Davis, Sacramento, California 95817, USA.
⁶ Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: Abass.Alavi@uphs.upenn.edu.

Abstract

In the current diagnostic paradigm, the substantial physical sensitivity gain is the main advantage of total-body (TB) PET/computed tomography (CT). Therefore, it is up to the imaging community to tailor protocols that take advantage of this unique innovation as it relates to the needs of the pediatric population. However, the paradigm-shifting promise of TB-PET/CT lies in its capability to perform dynamic, delayed, and low-dose imaging, which have the potential to vastly increase the range of diseases and disorders that can be investigated or managed using molecular imaging.

Keywords: Computed tomography; PET; Pediatrics; Total body.

Publication types

Review

MeSH terms

Child
Humans
Neoplasms / diagnostic imaging*
Positron Emission Tomography Computed Tomography / methods*
Radiation Dosage*
Time
Whole Body Imaging / methods*

Abstract

Publication types

MeSH terms

Grants and funding