Right heart catheterization (RHC) is a key diagnostic tool in several clinical conditions. It is recognized to be a technically demanding procedure requiring accurate evaluation of results. If performed by skilled operators, RHC provides reliable and valuable measurements with low complication rates. Although increasing data from the literature have become available over time, a comprehensive review of technical details and pitfalls is rare. This article aims to provide an overview of indications and evidence-based practical issues upon RHC to guide interventional cardiologists on how to perform this procedure.