Abstract
Analysis of sequencing data for 143 blaNDM-1- and blaOXA-48-positive Klebsiella pneumoniae isolates from 13 European national collections and the public domain resulted in the identification of 15 previously undetected multi-country transmission clusters. For 10 clusters, cases had prior travel/hospitalisation history in countries outside of the European Union including Egypt, Iran, Morocco, Russia, Serbia, Tunisia and Turkey. These findings highlight the benefit of European whole genome sequencing-based surveillance and data sharing for control of antimicrobial resistance.
Keywords:
Klebsiella pneumonia; OXA-48, NDM-1; carbapenem-resistant Enterobacterales; carbapenemase; cross-border import; surveillance; whole genome sequencing.
MeSH terms
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Anti-Bacterial Agents / therapeutic use
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Bacterial Proteins / genetics*
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Carbapenem-Resistant Enterobacteriaceae / drug effects
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Carbapenem-Resistant Enterobacteriaceae / genetics*
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Carbapenem-Resistant Enterobacteriaceae / isolation & purification*
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Carbapenems / therapeutic use
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Disease Outbreaks*
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Emigration and Immigration
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Humans
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Klebsiella Infections / drug therapy
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Microbial Sensitivity Tests / methods
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Whole Genome Sequencing / methods*
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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beta-Lactamases
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beta-lactamase NDM-1