Frontotemporal Dementia: Neuropathology, Genetics, Neuroimaging, and Treatments

Abstract

Frontotemporal dementia (FTD) encompasses a group of clinical syndromes, including behavioral variant FTD, nonfluent variant primary progressive aphasia, semantic variant primary progressive aphasia, FTD motor neuron disease, progressive supranuclear palsy syndrome, and corticobasal syndrome. Early on in its course, FTD is commonly seen in psychiatric clinics. In this article the authors review the neuroimaging, pathology, genetics, and therapeutic interventions for FTD spectrum disorders.

Keywords: Frontotemporal dementia; Genetics; Neuroimaging; Neuropathology.