Principles of Good Clinical Trial Design

J Thorac Oncol. 2020 Aug;15(8):1277-1280. doi: 10.1016/j.jtho.2020.05.005. Epub 2020 May 15.

Abstract

Clinical trials are a fundamental component of medical research and serve as the main route to obtain evidence of the safety and efficacy of treatment before its approval. A trial's ability to provide the intended evidence hinges on appropriate design, background knowledge, trial rationale to sample size, and interim monitoring rules. In this article, we present some general design principles for investigators and their research teams to consider when planning to conduct a trial.

Keywords: Clinical trial; Collaboration; Design; Principles.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomedical Research*
  • Clinical Trials as Topic
  • Humans
  • Lung Neoplasms*
  • Research Design