Dynamic reconfiguration of functional brain networks during working memory training

Nat Commun. 2020 May 15;11(1):2435. doi: 10.1038/s41467-020-15631-z.

Abstract

The functional network of the brain continually adapts to changing environmental demands. The consequence of behavioral automation for task-related functional network architecture remains far from understood. We investigated the neural reflections of behavioral automation as participants mastered a dual n-back task. In four fMRI scans equally spanning a 6-week training period, we assessed brain network modularity, a substrate for adaptation in biological systems. We found that whole-brain modularity steadily increased during training for both conditions of the dual n-back task. In a dynamic analysis,we found that the autonomy of the default mode system and integration among task-positive systems were modulated by training. The automation of the n-back task through training resulted in non-linear changes in integration between the fronto-parietal and default mode systems, and integration with the subcortical system. Our findings suggest that the automation of a cognitively demanding task may result in more segregated network organization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Algorithms
  • Behavior
  • Brain / physiology
  • Brain Mapping*
  • Cognition
  • Electronic Data Processing
  • Female
  • Humans
  • Learning
  • Magnetic Resonance Imaging
  • Male
  • Memory, Short-Term*
  • Models, Neurological
  • Models, Statistical
  • Nerve Net / physiology*
  • Signal Processing, Computer-Assisted
  • Young Adult