Resident Memory T Cells Escape 'Home Quarantine'

Marco Künzli; Carolyn G King

doi:10.1016/j.it.2020.04.010

Resident Memory T Cells Escape 'Home Quarantine'

Trends Immunol. 2020 Jun;41(6):454-456. doi: 10.1016/j.it.2020.04.010. Epub 2020 May 6.

Authors

Marco Künzli¹, Carolyn G King²

Affiliations

¹ Department of Biomedicine, University of Basel, University Hospital of Basel, CH-4031 Basel, Switzerland.
² Department of Biomedicine, University of Basel, University Hospital of Basel, CH-4031 Basel, Switzerland. Electronic address: carolyn.king@unibas.ch.

PMID: 32386961
DOI: 10.1016/j.it.2020.04.010

Abstract

T resident memory (Trm) cells provide a first line of defense in non-lymphoid tissues. A new report in Nature Immunology by Fonseca et al. reveals that CD8⁺ Trm cells can give rise to circulating effector and memory T cells, but remain predisposed to migrate back into their tissue of origin.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

CD8-Positive T-Lymphocytes
Humans
Immunologic Memory*
Quarantine*