High-Fidelity Modeling of Human Microglia with Pluripotent Stem Cells

Peng Jiang; Luka Turkalj; Ranjie Xu

doi:10.1016/j.stem.2020.04.004

High-Fidelity Modeling of Human Microglia with Pluripotent Stem Cells

Cell Stem Cell. 2020 May 7;26(5):629-631. doi: 10.1016/j.stem.2020.04.004.

Authors

Peng Jiang¹, Luka Turkalj², Ranjie Xu³

Affiliations

¹ Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: peng.jiang@rutgers.edu.
² Graduate Program in Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
³ Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.

Abstract

Gosselin et al. (2017) reported that a tissue-environment-dependent transcriptional network specifies human microglia identity and that in vitro environments drastically alter the human microglia transcriptome. Recent 3-dimensional culture and human-mouse chimeric brain modeling systems developed using human pluripotent stem cells help us understand the complex properties of human microglia.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Brain
Gene Regulatory Networks
Humans
Induced Pluripotent Stem Cells*
Mice
Microglia
Pluripotent Stem Cells*
Transcriptome

Abstract

Publication types

MeSH terms

Grants and funding