Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation

Yoko Nishinaka-Arai; Akira Niwa; Shiori Matsuo; Yasuhiro Kazuki; Yuwna Yakura; Takehiko Hiroma; Tsutomu Toki; Tetsushi Sakuma; Takashi Yamamoto; Etsuro Ito; Mitsuo Oshimura; Tatsutoshi Nakahata; Megumu K Saito

doi:10.3324/haematol.2019.242693

Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation

Haematologica. 2021 Feb 1;106(2):635-640. doi: 10.3324/haematol.2019.242693.

Authors

Affiliations

¹ Dept. of Clinical Application, Center for iPS cell Research and Application, Kyoto University, Kyoto.
² Chromosome Engineering Research Center, Tottori University, Tottori, Japan.
³ Perinatal Medical Center, Nagano Children's Hospital, Nagano, Japan.
⁴ Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
⁵ Division of Integrated Sciences for Life, Hiroshima University, Hiroshima, Japan.
⁶ Center for iPS cell Research and Application, Kyoto University, Kyoto, Japan.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Down Syndrome* / complications
Down Syndrome* / diagnosis
Down Syndrome* / genetics
GATA1 Transcription Factor / genetics
Humans
Leukemoid Reaction* / diagnosis
Leukemoid Reaction* / genetics
Mutation
Myelopoiesis / genetics

Substances

GATA1 Transcription Factor
GATA1 protein, human

Supplementary concepts

Myeloproliferative Syndrome, Transient

Grants and funding

Funding: this work was supported by grants from the Ministry of Health, Labour and Welfare of Japan, Ministry of Education, Culture, Sports, Science and Technology of Japan, Japan Society for the Promotion of Science (JSPS) Research Fellowships for Young Scientists [YNA], KAKENHI Grant Number 19K17358 [YNA], KAKENHI Grant Number 25221308 [MO] and KAKENHI Grant Number 16K10026 [AN], Regional Innovation Support Program from the Ministry of Education, Culture, Sports, Science and Technology of Japan [MO and YK], the Leading Project of the Ministry of Education, Culture, Sports, Science and Technology [TN], the Funding Program for World-Leading Innovative Research and Development on Science and Technology of the Japan Society for the Promotion of Science [TN and MKS], CREST [TN], the Core Center for iPS Cell Research of Research Center Network for Realization of Regenerative Medicine from the Japan Agency for Medical Research and Development (AMED) [TN and MKS], the Program for Intractable Diseases Research utilizing Disease-specific iPS cells of AMED (17935423) [YNA, TN and MKS], and Practical Research Project for Rare/Intractable Diseases of AMED (17930095) [MKS].