Simultaneous upper and lower urinary tract invasive Lymphoepithelioma-like carcinoma with programmed death-ligand 1 full expression on combined positive score

Che-Hsueh Yang; Yi-Sheng Lin; Wei-Chun Weng; Yen-Chuan Ou; Chao-Yu Hsu; Min-Che Tung

doi:10.1016/j.eucr.2020.101201

Simultaneous upper and lower urinary tract invasive Lymphoepithelioma-like carcinoma with programmed death-ligand 1 full expression on combined positive score

Urol Case Rep. 2020 Apr 10:31:101201. doi: 10.1016/j.eucr.2020.101201. eCollection 2020 Jul.

Authors

Che-Hsueh Yang¹, Yi-Sheng Lin¹, Wei-Chun Weng¹, Yen-Chuan Ou¹, Chao-Yu Hsu¹, Min-Che Tung¹

Affiliation

¹ Division of Urology, Department of Surgery, Tungs' Taichung MetroHarbor Hospital, No. 699, Sec. 8, Taiwan Blvd., Wuqi Dist., Taichung City, 43503, Taiwan.

Abstract

Lymphoepithelioma-like carcinoma, named after nasopharyngeal lymphoepithelioma and rarely seen at genitourinary malignancy, accounts for 1%-2% along the upper and lower urinary tract. For its rarity, no published guideline can be adhered to. Roles of surgery and chemotherapy are solid, and rich Programmed Death-Ligand 1 characteristics may furthermore light on the possible immunotherapy. This female case had it at both upper and lower urinary tract simultaneously. No involved regional lymph nodes and no distant metastasis were investigated. No adjuvant chemotherapy was given after robotics-assisted left nephroureterectomy and bladder cuff excision with partial cystectomy, and no recurrence was observed.

Keywords: Combined positive score; Lymphoepithelioma-like carcinoma; Programmed death-ligand 1; Urinary tract tumor.

Publication types

Case Reports