Fatal Fulminant Legionnaires' Disease in a Patient on Maintenance Hemodialysis

Intern Med. 2020 Aug 1;59(15):1913-1918. doi: 10.2169/internalmedicine.4530-20. Epub 2020 Apr 23.

Abstract

We herein report a case of fulminant Legionnaires' disease with autopsy findings in a patient on maintenance hemodialysis (HD). Chronic kidney disease is a strong risk factor for Legionnaires' disease, although there have been only a few reports in HD patients. Because most patients on HD are anuric, the use of rapid assay kits to detect antigens in urine samples for the diagnosis of Legionnaires' disease is not always feasible. We suggest the use of clinical predictive tools or the loop-mediated isothermal amplification (LAMP) method, which can be applied for anuric patients, such as those on HD, with pneumonia.

Keywords: Legionella pneumophila; atypical pneumonia; hemodialysis patients; immunocompromised hosts.

Publication types

  • Case Reports

MeSH terms

  • Autopsy
  • Humans
  • Legionella pneumophila
  • Legionnaires' Disease / diagnosis*
  • Legionnaires' Disease / etiology*
  • Male
  • Middle Aged
  • Molecular Diagnostic Techniques
  • Nucleic Acid Amplification Techniques
  • Renal Dialysis / methods
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / therapy

Supplementary concepts

  • LAMP assay