SnapShot: Cancer-Associated Fibroblasts

Danielle Park; Erik Sahai; Antonio Rullan

doi:10.1016/j.cell.2020.03.013

SnapShot: Cancer-Associated Fibroblasts

Cell. 2020 Apr 16;181(2):486-486.e1. doi: 10.1016/j.cell.2020.03.013.

Authors

Danielle Park¹, Erik Sahai¹, Antonio Rullan²

Affiliations

¹ Tumour Cell Biology Laboratory, Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
² Tumour Cell Biology Laboratory, Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK; Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.

PMID: 32302576
DOI: 10.1016/j.cell.2020.03.013

Abstract

Cancer-associated fibroblasts (CAFs) are an integral component of the tumor microenvironment and have both tumor-promoting and tumor-suppressive functions. This SnapShot summarizes the origins of CAFs, their diverse functions, and how this relates to heterogeneity within the population. The suitability of targeting CAFs therapeutically is also discussed.

MeSH terms

Biomarkers, Tumor
Cancer-Associated Fibroblasts / metabolism
Cancer-Associated Fibroblasts / pathology*
Cancer-Associated Fibroblasts / physiology*
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic / pathology
Disease Progression
Fibroblasts / pathology
Fibroblasts / physiology
Humans
Neoplasms / metabolism
Neoplasms / physiopathology
Tumor Microenvironment / physiology*

Substances

Biomarkers, Tumor