High prevalence of Cryptosporidium infection caused by C. scrofarum and C. suis among pigs in Thailand

Parasitol Int. 2020 Aug:77:102122. doi: 10.1016/j.parint.2020.102122. Epub 2020 Apr 9.

Abstract

Cryptosporidium spp. is an important intestinal protozoan causing diarrhea among both healthy and immunocompromised patients especially those with HIV/AIDS. Cryptosporidium spp. can be transmitted via foodborne, waterborne and person-to-person routes. In addition, several Cryptosporidium species are zoonotic. This study aimed to determine the prevalence of Cryptosporidium infection among pigs raised in both smallholder (<50 heads/farm) and large scale farms (50-500 heads/farm) in Chonburi Province, eastern Thailand using nested PCR amplifying the small subunit of the ribosomal RNA (SSU-rRNA) gene. DNA sequencing was also performed to identify the species of Cryptosporidium. A total of 245 fecal samples were collected from 11 pig farms. The overall prevalence of Cryptosporidium infection was 20.8% (51/245) which were found in both smallholder and small large scale pig farms. The prevalence of Cryptosporidium infection among pigs aged ≤6 months was significantly higher than those aged >6 months (p < .001). Among 51 Cryptosporidium positive samples, Cryptosporidium scrofarum (42/51, 82.4%) and Cryptosporidium suis (9/51, 17.6%) were identified. The prevalence of C. scrofarum infection observed among pigs aged ≤6 months was significantly higher when compared with those aged >6 months (20.7% and 2.1%, respectively, p < .001). The high prevalence of C. scrofarum and C. suis infections among pigs could be a potential source of infection to humans.

Keywords: C. scrofarum; C. suis; Cryptosporidium; Pig; Thailand; Zoonotic.

MeSH terms

  • Animals
  • Cryptosporidiosis / epidemiology*
  • Cryptosporidiosis / parasitology
  • Cryptosporidiosis / transmission
  • Cryptosporidium / classification*
  • Cryptosporidium / genetics*
  • Cryptosporidium / isolation & purification
  • Farms / statistics & numerical data
  • Feces / parasitology
  • Female
  • Male
  • Phylogeny
  • Prevalence
  • RNA, Ribosomal, 18S / genetics
  • Sequence Analysis, DNA
  • Swine / parasitology
  • Swine Diseases / epidemiology*
  • Swine Diseases / parasitology
  • Thailand / epidemiology

Substances

  • RNA, Ribosomal, 18S