Complete Genome Sequences of the Human Pathogen Paenibacillus thiaminolyticus Mbale and Type Strain P. thiaminolyticus NRRL B-4156

Christine Hehnly; Lijun Zhang; Joseph N Paulson; Mathieu Almeida; Benjamin von Bredow; Dona S S Wijetunge; Michael Y Galperin; Kathryn Sheldon; Steven J Schiff; James R Broach

doi:10.1128/MRA.00181-20

Complete Genome Sequences of the Human Pathogen Paenibacillus thiaminolyticus Mbale and Type Strain P. thiaminolyticus NRRL B-4156

Microbiol Resour Announc. 2020 Apr 9;9(15):e00181-20. doi: 10.1128/MRA.00181-20.

Authors

Christine Hehnly^{1

2}, Lijun Zhang^{1

2}, Joseph N Paulson³, Mathieu Almeida⁴, Benjamin von Bredow⁵, Dona S S Wijetunge⁵, Michael Y Galperin⁶, Kathryn Sheldon^{1

2}, Steven J Schiff^{7

8

9

10}, James R Broach^{11

2}

Affiliations

¹ Penn State Institute for Personalized Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
² Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
³ Department of Biostatistics, Product Development, Genentech, Inc., South San Francisco, California, USA.
⁴ MetaGénoPolis, INRA, Université Paris-Saclay, Jouy-en-Josas, France.
⁵ Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
⁶ National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
⁷ Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
⁸ Penn State Center for Neural Engineering, The Pennsylvania State University College of Engineering, University Park, Pennsylvania, USA.
⁹ Department of Engineering Science and Mechanics, The Pennsylvania State University College of Engineering, University Park, Pennsylvania, USA.
¹⁰ Department of Physics, The Pennsylvania State University Eberly College of Science, University Park, Pennsylvania, USA.
¹¹ Penn State Institute for Personalized Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA jbroach@pennstatehealth.psu.edu.

Abstract

We have isolated a likely bacterial pathogen from cerebrospinal fluid from a Ugandan infant suffering from hydrocephalus. Whole-genome sequencing and assembly of the genome of the clinical isolate, as well as that of a previously deposited reference strain, identified the isolate as Paenibacillus thiaminolyticus, which has not been associated with widespread human infections.

Grants and funding

DP1 HD086071/HD/NICHD NIH HHS/United States