Occupational exposure of dental technicians to methyl methacrylate: Genotoxicity assessment

Mutat Res Genet Toxicol Environ Mutagen. 2020 Apr:852:503159. doi: 10.1016/j.mrgentox.2020.503159. Epub 2020 Feb 25.

Abstract

Dental technicians may be chronically exposed to methyl methacrylate (MMA), used in the production of dental prostheses. We have studied whether occupational exposure to MMA affects genotoxicity biomarkers such as 8-OHdG formation, comet assay, and buccal micronucleus frequency. MMA exposure was assessed via ambient air analysis. Although no significant differences between exposed and non-exposed individuals were seen with respect to blood genotoxicity measurements, we found a higher level of buccal-cell anomalies in the exposed group.

Keywords: 8-OHdG; Adaptive response; Buccal micronucleus; COMET assay; Cytome assay; Methyl methacrylate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine / blood
  • Adult
  • Bone Cements / toxicity*
  • Case-Control Studies
  • Comet Assay
  • DNA Damage
  • Dental Technicians*
  • Female
  • Humans
  • Male
  • Methylmethacrylate / toxicity*
  • Micronuclei, Chromosome-Defective / drug effects*
  • Micronucleus Tests
  • Mouth Mucosa / cytology
  • Mouth Mucosa / drug effects*
  • Occupational Exposure / analysis

Substances

  • Bone Cements
  • Methylmethacrylate
  • 8-Hydroxy-2'-Deoxyguanosine