Fabrication of tumor necrosis factor-related apoptosis inducing ligand (TRAIL)/ALG modified CaCO3 as drug carriers with the function of tumor selective recognition

Wei Cui; Yue Cui; Jie Zhao; Junbai Li

doi:10.1039/c2tb00293k

Fabrication of tumor necrosis factor-related apoptosis inducing ligand (TRAIL)/ALG modified CaCO₃ as drug carriers with the function of tumor selective recognition

J Mater Chem B. 2013 Mar 7;1(9):1326-1332. doi: 10.1039/c2tb00293k. Epub 2013 Jan 24.

Authors

Wei Cui¹, Yue Cui, Jie Zhao, Junbai Li

Affiliation

¹ Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. jbli@iccas.ac.cn.

PMID: 32260806
DOI: 10.1039/c2tb00293k

Abstract

Layer-by-layer assembled TRAIL/ALG shells have been successfully coated on the surface of highly loaded doxorubicin (DOX) calcium carbonate (CaCO₃) nanoparticles as drug carriers. The assembled core/shell structure was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). They show that the assembled TRAIL/ALG coated DOX@CaCO₃ nanocomposites can be internalized by cancer cells. The outer layer of the system is TRAIL which can be specifically recognized by tumors and leads to the apoptosis of tumors. The release of DOX can directly kill the cancer cells. This demonstrates that the core/shell nanocomposites of TRAIL/ALG-CaCO₃ loaded with DOX have good potential applications in the treatment of cancer.