Evidence against location of the gene for facioscapulohumeral muscular dystrophy on the distal long arm of chromosome 14

P W Lunt; J G Noades; M Upadhyaya; M Sarfarazi; P S Harper

doi:10.1016/0022-510x(88)90225-0

Evidence against location of the gene for facioscapulohumeral muscular dystrophy on the distal long arm of chromosome 14

J Neurol Sci. 1988 Dec;88(1-3):287-92. doi: 10.1016/0022-510x(88)90225-0.

Authors

P W Lunt¹, J G Noades, M Upadhyaya, M Sarfarazi, P S Harper

Affiliation

¹ Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, U.K.

PMID: 3225626
DOI: 10.1016/0022-510x(88)90225-0

Abstract

A panel of 399 individuals from 24 kindreds with facioscapulohumeral muscular dystrophy (FSHD) has been established for genetic linkage studies. A previous suggestion of linkage on the distal long arm of chromosome 14 to the locus (IGHG) for the constant region of the heavy chain of IgG immunoglobulin was tested from serum Gm allotypes and from DNA analysis using an IGHG DNA probe. After applying an age-dependent weighting for presently unaffected but at risk individuals close linkage between the IGHG and FSHD loci was excluded.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Child
Child, Preschool
Chromosomes, Human, Pair 14*
Facial Muscles / physiopathology*
Female
Genetic Linkage
Humans
Humerus / physiopathology
Infant
Male
Muscular Dystrophies / genetics*
Scapula / physiopathology