Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release

Yuxiang Chen; Somia Yassin Hussain Abdalkarim; Hou-Yong Yu; Yingzhan Li; Jiaxin Xu; Jaromir Marek; Juming Yao; Kam Chiu Tam

doi:10.1016/j.ijbiomac.2020.03.216

Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release

Int J Biol Macromol. 2020 Jul 15:155:330-339. doi: 10.1016/j.ijbiomac.2020.03.216. Epub 2020 Mar 27.

Authors

Yuxiang Chen¹, Somia Yassin Hussain Abdalkarim², Hou-Yong Yu³, Yingzhan Li¹, Jiaxin Xu⁴, Jaromir Marek⁵, Juming Yao¹, Kam Chiu Tam⁴

Affiliations

¹ Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China.
² Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China; Zhejiang Institute of Technology and Automatic Control, College of Mechanical and Automatic Control, Zhejiang Sci-Tech University, Hangzhou 310018, China.
³ Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China; Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada. Electronic address: phdyu@zstu.edu.cn.
⁴ Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada.
⁵ Institute for Nanomaterials, Advanced Technologies And Innovations, Studentska 1402/2, Liberec, Czech Republic.

PMID: 32229207
DOI: 10.1016/j.ijbiomac.2020.03.216

Abstract

Double stimuli-responsive functionalized cellulose nanocrystal-poly[2-(dimethylamino)ethyl methacrylate] (CNC-g-PDMAEMA) reinforced poly(3-hydroxybutyrate-co-3-hydroxy valerate) (PHBV) electrospun composite membranes were explored as drug delivery vehicles using tetracycline hydrochloride (TH) as a model drug. It was found that rigid CNC-g-PDMAEMA nanoparticles enhanced thermal, crystallization and hydrophilic properties of PHBV. Moreover, great improvements in fiber diameter uniformity, crystallization ability and maximum decomposition temperature (T_max) could be achieved at 6 wt% CNC-g-PDMAEMA. Furthermore, by introducing stimuli-responsive CNC-g-PDMAEMA nanofillers, intelligent and long-term sustained release behavior of composite membranes could be achieved. The releasing mechanism of composite membranes based on zero order, first order, Higuchi and Korsmeyere-Peppas mathematical models was clearly demonstrated, giving effective technical guidance for practical drug delivery systems.

Keywords: Cellulose nanocrystals; Drug release; Electrospinning; Nanofiber membrane.

MeSH terms

Cellulose / chemistry*
Crystallization
Drug Liberation*
Hydrophobic and Hydrophilic Interactions
Membranes / chemistry
Methacrylates / chemistry*
Models, Theoretical
Nanocomposites / chemistry*
Nanoparticles / chemistry*
Nylons / chemistry*
Temperature

Substances

Methacrylates
Nylons
poly(2-(dimethylamino)ethyl methacrylate)
Cellulose